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KMID : 0379520030190030205
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한국독성학회지
2003 Volume.19 No. 3 p.205 ~ p.210
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Association between I/D Polymorphism of Human LRPAP1 Gene and Body Mass Index in Korean General Population
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Kang Byung-Yong
Bae Hak-Gyoon
Jhin Hea-Kyung
Lee Kyung-Soon
Lee Kang-Oh
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Abstract
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The aim of this study was to estimate the influence of 37 bp insertion/deletion (I/O) poly-morphism of the low density lipoprotein receptor-related protein-associated protein 1 (LRPAP1) gene on anthropometrical or biochemical parameters in korean general population. To determine the frequency of the genotype, we analyzed 244 samples of Korean origin. The frequency of the I allele was 0.55 in men and 0.56 in women, which were significantly higher than the frequency (0.26) that was reported in Czech population of Caucasian origin. In addition, the I allele of this polymorphism was significantly associated with higher value of body mass index (BMI) in our subjects by ANOVA test (P<0.05), and this association was maintained after controlling for age and gender by ANCOVA test (P<0.05). Thus, our results suggest that the I/O polymorphism of the LRPAP1 gene may be useful as a genetic marker for obesity in Korean general population.
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KEYWORD
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Body Mass Index, Genotype, LRPAP1
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